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Lars Gullestad Selected Research

Interleukin-6 Receptors (Interleukin 6 Receptor)

1/2021Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction.
1/2021Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction.
1/2019Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction.
1/2019Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of tocilizumab on myocardial salvage in patients with acute ST-elevation myocardial infarction (STEMI).
11/2018Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction.
1/2018Serum PCSK9 is modified by interleukin-6 receptor antagonism in patients with hypercholesterolaemia following non-ST-elevation myocardial infarction.
1/2018IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction.
10/2017Effect of interleukin-6 inhibition on coronary microvascular and endothelial function in myocardial infarction.
8/2016Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial.

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Lars Gullestad Research Topics

Disease

96Heart Failure
04/2022 - 01/2001
57Inflammation (Inflammations)
01/2022 - 11/2002
33Coronary Artery Disease (Coronary Atherosclerosis)
01/2021 - 07/2002
26Myocardial Infarction
12/2021 - 03/2004
22Atherosclerosis
01/2022 - 07/2002
13Acute Coronary Syndrome
10/2020 - 07/2002
11Atherosclerotic Plaque (Atheroma)
10/2019 - 07/2002
10Cardiovascular Diseases (Cardiovascular Disease)
01/2022 - 05/2006
10Non-ST Elevated Myocardial Infarction
01/2021 - 03/2016
9Type 2 Diabetes Mellitus (MODY)
11/2021 - 09/2010
9Infarction (Infarctions)
01/2021 - 03/2004
9Unstable Angina
01/2018 - 07/2002
8ST Elevation Myocardial Infarction
06/2022 - 01/2013
8Aortic Valve Stenosis (Aortic Stenosis)
01/2022 - 08/2011
8Atrial Fibrillation
01/2022 - 03/2004
8Stroke (Strokes)
12/2021 - 03/2011
8Fibrosis (Cirrhosis)
11/2018 - 03/2003
7Necrosis
10/2020 - 01/2001
7Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
09/2017 - 09/2004
6Systolic Heart Failure
04/2022 - 11/2007
6Hypertrophy
06/2012 - 03/2003
5Hypertension (High Blood Pressure)
01/2022 - 11/2002
5Myocardial Ischemia (Ischemic Heart Diseases)
09/2017 - 01/2013
4Iron Deficiencies
01/2022 - 01/2021
4Coronary Disease (Coronary Heart Disease)
11/2021 - 01/2017
4Neoplasms (Cancer)
10/2020 - 11/2004
4Stable Angina
10/2020 - 07/2002
4Diabetes Mellitus
01/2020 - 03/2013
4Cardiomyopathies (Cardiomyopathy)
11/2014 - 10/2003
4Renal Insufficiency (Renal Failure)
03/2012 - 03/2007
3Anemia
04/2022 - 01/2012
3Infections
01/2022 - 03/2007
3Sleep Apnea Syndromes (Sleep Apnea)
01/2022 - 12/2018
3Carotid Artery Diseases
10/2020 - 01/2013
3Hypoxia (Hypoxemia)
09/2017 - 01/2004
3Ischemia
09/2017 - 09/2012
3Ventricular Remodeling
01/2014 - 09/2013
3Left Ventricular Dysfunction
08/2011 - 05/2005
2Skeletal Abnormalities Mandibular Hypoplasia Auditory Canal Atresia Short Stature
11/2021 - 06/2019
2Death (Near-Death Experience)
01/2021 - 09/2009
2Overweight
01/2021 - 12/2017

Drug/Important Bio-Agent (IBA)

30CytokinesIBA
04/2022 - 01/2001
25Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
11/2021 - 01/2003
20Rosuvastatin Calcium (Crestor)FDA Link
11/2019 - 11/2007
16Troponin T (Troponin T1)IBA
06/2022 - 09/2010
16pro-brain natriuretic peptide (1-76)IBA
01/2022 - 05/2007
15ChemokinesIBA
01/2014 - 07/2002
14Interleukin-6 (Interleukin 6)IBA
06/2022 - 01/2013
14Brain Natriuretic Peptide (Natrecor)FDA Link
01/2022 - 03/2004
14C-Reactive ProteinIBA
01/2020 - 04/2004
13Proteins (Proteins, Gene)FDA Link
01/2022 - 07/2002
13Biomarkers (Surrogate Marker)IBA
01/2022 - 05/2007
12tocilizumab (atlizumab)FDA Link
06/2022 - 08/2016
12LigandsIBA
01/2020 - 10/2003
10Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2012 - 01/2001
9Interleukin-6 Receptors (Interleukin 6 Receptor)IBA
01/2021 - 08/2016
8LipidsIBA
08/2019 - 04/2004
8OsteoprotegerinIBA
05/2015 - 11/2004
7Messenger RNA (mRNA)IBA
01/2020 - 07/2002
7EverolimusFDA Link
01/2018 - 06/2010
7Metoprolol (Toprol-XL)FDA LinkGeneric
02/2016 - 03/2002
6Trinitrotoluene (TNT)IBA
06/2022 - 06/2011
6IronIBA
04/2022 - 01/2018
5InterleukinsIBA
06/2022 - 06/2003
5Ferritins (Ferritin)IBA
04/2022 - 01/2018
5CholesterolIBA
11/2021 - 10/2002
5Natriuretic PeptidesIBA
10/2020 - 05/2007
5Pharmaceutical PreparationsIBA
12/2017 - 03/2004
5Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
01/2014 - 07/2002
5CreatinineIBA
04/2012 - 11/2003
4Darbepoetin alfa (Aranesp)FDA Link
04/2022 - 01/2018
4Atorvastatin (Lipitor)FDA Link
11/2021 - 01/2003
4Glucose (Dextrose)FDA LinkGeneric
11/2021 - 07/2012
4oxidized low density lipoproteinIBA
01/2018 - 01/2004
4Interleukin-8 (Interleukin 8)IBA
01/2014 - 07/2002
4Intravenous Immunoglobulins (IVIG)FDA Link
09/2013 - 03/2004
4activin AIBA
08/2013 - 03/2004
4Galectin 3 (LGALS3)IBA
03/2013 - 08/2011
4RANK LigandIBA
06/2009 - 05/2005
4Matrix Metalloproteinases (MMPs)IBA
11/2007 - 05/2005
3RNA (Ribonucleic Acid)IBA
06/2022 - 07/2004
3Transferrin (beta 2 Transferrin)IBA
01/2022 - 01/2018
3Complement System Proteins (Complement)IBA
01/2021 - 01/2017
3CollagenIBA
03/2015 - 10/2005
3Angiotensin Receptor AntagonistsIBA
01/2015 - 03/2013
3Mannose-Binding Lectin (Mannan-Binding Lectin)IBA
01/2013 - 08/2005
3Apolipoproteins E (ApoE)IBA
08/2009 - 04/2006
3Toll-Like Receptors (Toll-Like Receptor)IBA
05/2009 - 03/2006
3Thalidomide (Thalomid)FDA Link
01/2007 - 11/2002
3CD40 Ligand (CD40L)IBA
06/2005 - 01/2003
2InflammasomesIBA
01/2022 - 10/2020
2trimethyloxamine (trimethylamine N-oxide)IBA
08/2021 - 10/2019

Therapy/Procedure

26Therapeutics
01/2022 - 01/2003
13Heart Transplantation (Grafting, Heart)
01/2022 - 09/2003
4Continuous Positive Airway Pressure
01/2022 - 12/2018
4Transplantation
12/2021 - 03/2007
4Percutaneous Coronary Intervention
01/2021 - 03/2016
4Coronary Artery Bypass (Coronary Artery Bypass Surgery)
01/2018 - 05/2013
4Ligation
09/2017 - 11/2009
3Cardiac Resynchronization Therapy
05/2014 - 06/2011